Villa Hendrikx / 70F Architecture

first_imgShareFacebookTwitterPinterestWhatsappMailOr Clipboard Year:  Photographs:  Luuk KramerText description provided by the architects. The house is a two-story building with traditional planning, living on the ground floor and sleeping upstairs. The building is divided into three parts: a two-storey main entrance building facing the front garden, a patio and connecting hallway as an open area in between, and finally the living area in a one-story volume in the middle of the plot. Save this picture!© Luuk KramerRecommended ProductsWoodLunawoodThermo Timber and Industrial ThermowoodEnclosures / Double Skin FacadesRodecaRound Facade at Omnisport Arena ApeldoornFiber Cements / CementsULMA Architectural SolutionsPaper Facade Panel in Leioa School RestorationFiber Cements / CementsEQUITONEFiber Cement Facade Panel NaturaThe house is clad in yellow-white blend brickwork with mahogany window frames. The first (twostory) block contains an office with business entrance and bathroom, utility room, storage room and sauna on the ground floor. On the first floor are the bedrooms, bath and shower rooms. The landing is so spacious, that besides the traffic space there is place for a cabinet wall, which maximizes the free space in the bedrooms, but also a large workbench. On this workbench, the three children do their homework and use their computers. This encourages social contact within the family, but also provides the necessary social supervision by the parents. None of the rooms in this volume are street-oriented, to emphasize privacy. Save this picture!© Luuk KramerThe entrance to the house is in the second volume, the connecting hallway between the tall office/sleep volume and the low residential volume. It also houses the start of the stairs to the first floor, while more towards the living quarters there is a cloakroom. The third volume is divided into three parts. The dining/TV area is focused on the east side garden. The kitchen is built into two long volumes, separating the living room from the dining room. Above the kitchen is a glass roof. In these volumes there are also an indoor and an outdoor fireplace. The livingroom is facing the patio and the backyard, and has a partly covered terrace facing south. Save this picture!By dividing the various functions into multiple, interconnected blocks, the house becomes fully integrated with the plot. The phenomenal large glass panes, the visual lines of the interior design and the garden design by the Mien Ruys studio do the rest. Save this picture!© Luuk KramerProject gallerySee allShow lessRichard Meier Retrospective Exhibition in Mexico CityArticles’CoExistence’ Badel Block Proposal / PlaCArticles Share Villa Hendrikx / 70F Architecture “COPY” “COPY” ShareFacebookTwitterPinterestWhatsappMailOr Clipboard The Netherlands Houses CopyHouses•Almere, The Netherlandscenter_img Architects: 70F Architecture Year Completion year of this architecture project Save this picture!© Luuk Kramer+ 23 Share Villa Hendrikx / 70F ArchitectureSave this projectSaveVilla Hendrikx / 70F Architecture Photographs Projects ArchDaily 2009 CopyAbout this office70F ArchitectureOfficeFollowProductBrick#TagsProjectsBuilt ProjectsSelected ProjectsResidential ArchitectureHousesAlmereHousesThe NetherlandsPublished on June 14, 2012Cite: “Villa Hendrikx / 70F Architecture” 14 Jun 2012. ArchDaily. Accessed 11 Jun 2021. ISSN 0719-8884Read commentsBrowse the CatalogShowershansgroheShower MixersVinyl Walls3MVinyl Finish – DI-NOC™ Abrasion ResistantPartitionsSkyfoldIntegrating Operable Walls in a SpaceLightsVibiaLamps – NorthCultural / PatrimonialIsland Exterior FabricatorsSeptember 11th Memorial Museum Envelope SystemSkylightsVELUX CommercialAtrium Longlight, DZNE GermanyHanging LampsLouis PoulsenLamp – PH ArtichokeTiles / Mosaic / GresiteHisbalitMosaic Tiles – TexturasAcousticMetawellAluminum Panels – Acoustic SailsMineral / Organic PaintsKEIMTiO2-free Mineral Paint – Soldalit®-ArteWall / Ceiling LightsA-LightWall Grazer Concealed LightsDoorsBuster and PunchDoor Hardware – Pull BarMore products »Read commentsSave想阅读文章的中文版本吗?亨德里克斯别墅 / 70F Architecture是否翻译成中文现有为你所在地区特制的网站?想浏览ArchDaily中国吗?Take me there »✖You’ve started following your first account!Did you know?You’ll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my streamlast_img read more

High Tax Assessments Possible Cause for Growing Foreclosure Rate

first_img Servicers Navigate the Post-Pandemic World 2 days ago Demand Propels Home Prices Upward 2 days ago Data Provider Black Knight to Acquire Top of Mind 2 days ago Related Articles Tagged with: assessments Constitution Detroit foreclosure rate limit Michigan property values About Author: Dean Terrell Subscribe Demand Propels Home Prices Upward 2 days ago According to an article from The Washington Post, high assessments may be to blame for Detroit, Michigan’s foreclosure crisis. Two college professors, Bernadette Atuahene and Tim Hodges, published a study making the case that the property tax on thousands of homes’ were illegally assessed. In 2015, Detroit had one of the highest foreclosure rates at 3,949 foreclosures per 100,000 people.In an article from Detroit Free Press, Atuahene cited data from her previous study titled “Stagegraft” last year showing a consistent rate of tax assessments higher than what the Michigan State Constitution allows from 2009-2015. “In our study, we find that Detroit’s assessor is flagrantly violating this vital state constitutional provision” Atuahene told the Press.The Michigan constitution states homes cannot be assessed at more than 50 percent of its market value. However, data from Atuahene’s most recent report suggests that between 55 and 85 percent of homes were assessed well above the legal amount from 2008 to 2015, according to the Post. More than 160,000 homes have been foreclosed on in Detroit since 2002.Another important detail is how certain properties were targeted based on property values. Data showed cheaper properties were more likely to be assessed higher than the more expensive ones. In an interview, Atuahene states “We found in [the lowest priced homes] 95 percent or more were being assessed in violation of the Michigan constitution. But when you get to the highest valued homes, only 13 percent were assessed in violation.”In the article from the Post, Detroit Chief Assessor Alvin Horhn disputed the findings of the more recent study which is planned to be published next year. “Much of the data does not meet the standards of the State Tax Commission. Therefore its findings would not be applicable under Michigan law” Horhn told the Post. The Best Markets For Residential Property Investors 2 days ago Previous: Big Banks and FinTech: Do American Consumers Want Both? Next: Fannie Mae Makes Fifth Sale of Reperforming Loans High Tax Assessments Possible Cause for Growing Foreclosure Rate assessments Constitution Detroit foreclosure rate limit Michigan property values 2017-10-11 Dean Terrell in Daily Dose, Featured, Foreclosure, Journal  Print This Post The Best Markets For Residential Property Investors 2 days ago Share Save Governmental Measures Target Expanded Access to Affordable Housing 2 days ago Servicers Navigate the Post-Pandemic World 2 days ago October 11, 2017 1,658 Views The Week Ahead: Nearing the Forbearance Exit 2 days ago Data Provider Black Knight to Acquire Top of Mind 2 days ago Governmental Measures Target Expanded Access to Affordable Housing 2 days ago Sign up for DS News Daily Home / Daily Dose / High Tax Assessments Possible Cause for Growing Foreclosure Ratelast_img read more

Ocean City Realtors Helping Needy Families With Winter Clothing Drive

first_imgOcean City Board of Realtors members Gloria Votta and Ken Cooper arrange the donations during the 2018 clothing drive. By Maddy VitaleStephen Hoffman walked into the Ocean City Board of Realtors office, said hello and turned to enter a room while toting a stuffed garbage bag.He knelt down, opened the bag and pulled out blankets, coats and other items that he placed on tables. “They’re not all from me. They are from my office,” said the sales representative with the real estate company, Marr Agency, in Ocean City.Then Hoffman said with a chuckle, “I’m just the delivery guy.”The items were part of the “Warmth for Winter Coat, Blanket & Boot Drive” in which the realtors and other members of the community collect items for the needy. The clothing drive is organized by the Board of Realtors in cooperation with the Clothes Closet of the Ocean City Ecumenical Council, an association of local churches that gives families in need some assistance. Stephen Hoffman, a sales rep with the Marr Agency in Ocean City, brings a bag of clothing he and his co-workers donated.The Ocean City Board of Realtors has been working along with the Ecumenical Council on the clothing drive for more than a decade, organizers said.“We are the people who are out in the community and we see what is happening,” said Ken Cooper, president of the Ocean City Board of Realtors. “A lot of us make a good living. We should give back. If you are not using something and it is just in your closet, donate it.”Cooper said there is plenty of time to donate clothing and other items. The clothing drive runs through the week after Thanksgiving, but the realtors will still accept donations through December. Then they will transport the items to the Ecumenical Clothes Closet in Ocean City.Cooper said people in need should never feel bad about accepting free clothing or other necessities.“If there are people in the community who have a need, they should come in. Some people are too embarrassed or fear the unknown,” he explained. “We do this because we want people to have warm clothes. We want to help others.”In just a couple of weeks, the conference room at the Board of Realtors filled up with all styles and sizes of coats and boots. The clothing was neatly arranged or folded on the tables. The boots, bedding and socks were stowed underneath in bags.Some garments still had the price tags on them. Clothing by Calvin Klein and Jones of New York and other brand names, lined the tables.Ken Cooper arranges jackets and sweatshirts, including some that still have the price tags on them.Gloria Votta, an agent for Re/Max Realty Group and chairwoman of the Community Services Committee for the Board of Realtors, helped start the drive.Like Cooper, she helps the needy because she wants to give back to the community.As a real estate agent, she has seen many different circumstances, she emphasized.“Not everyone sees this need in Ocean City,” Votta said. “You have to be out and about in the community to see the need. It is there.”She recalled an instance last year in which a man came in looking for size 9 sneakers.“We didn’t have any sneakers,” she said. The man left and in walked another man with a bag of sneakers he wanted to donate, Votta explained.“There was a size 9. We contacted the man and delivered the sneakers to him,” she said with a smile.The sign on the front door at the Ocean City Board of Realtors welcomes the community to donate to the clothing drive.She said there are many other touching stories and all of them are proof that the most important and rewarding thing to do is to help others.“Anyone who is a resident in Ocean City can go to the Ecumenical Clothes Closet and pick up their clothing,” Votta said.She added that the number of items a person may take depends on their needs. She said the Ecumenical Council handles that aspect of the clothing drive.Votta said this year, like last year, they are light on donations of children’s boots and men’s clothing.“We get a lot of women’s clothing,” Votta said. “If you go shopping on Black Friday, we are really in need of children’s snow boots.”Cash donations are also accepted. Votta said cash donations are used for shopping trips to purchase clothes for the needy, as requested by the Ecumenical Clothes Closet.Clothing donations may be dropped off at the Board of Realtors office at 405 22nd Street. To arrange for clothing pickups, people may call the office at (609) 399-0128. The office is open Monday through Friday from 9 a.m. to 5 p.m.Clothes are given out at the Ecumenical Clothes Closet at Fifth Street and West Avenue. The hours are 10 a.m. to 3 p.m. Monday and Wednesday and 10 a.m. to 2:30 p.m. Friday. Any leftover clothing is donated to the Atlantic City Rescue Mission, a homeless shelter.The Ocean City Board of Realtors is located at 405 22nd Street.last_img read more

Local GAA results

first_imgAherlow Gaels beat Ardfinnan on a scoreline of 2-14 to 1-14 last eveningAlso in Group 2 Moyle Rovers were 2-20 to 1-6 winners over Ballyporeen.In Group 1 Kilsheelan Kilcash and Eire Og Annacarty Donohill played out a thrilling 14 points to 1-11 draw. Former County Board chairman Sean Nugent was at the game in Leahy Park and felt the draw was probably a fair result.Meanwhile in yesterdays Rice Cup Under 14 schools hurling final Thurles CBS overcame Nenagh CBS on a scoreline of 3-16 to 2-9.last_img read more

This Kobe Bryant injury devastating to Lakers

first_img Newsroom GuidelinesNews TipsContact UsReport an Error The Lakers can barely keep enough healthy bodies to run point guard, let alone keep their season alive. Just a few hours after the news broke, Bryant Tweeted: “BrokenNotBeaten.”Surely, he hasn’t had enough time to digest how devastating this is for the Lakers.The Lakers have been beaten down with injuries, so much so that vision of playoffs dancing in their heads are more like hallucinations. Steve Nash, Steve Blake and Jordan Farmar are all still out along with the newly-injured Bryant. Xavier Henry is the newest starting point guard for the Lakers, and most fans still don’t even know how to pronounce his name correctly. If the season ended today, the Lakers would miss the playoffs anyway. Now that the 35-year-old Bryant won’t return until late January or early February at the earliest, the chances for playoffs are much more slim.Lakers coach Mike D’Antoni said that championships are the theme when he took this job for the fired Mike Brown. This, of course, despite D’Antoni having never won an NBA title.The gloomy Thursday was the perfect backdrop at the Toyota Sports Center now that the Lakers are doomed.If all goes well for Bryant, he won’t return until just before the All-Star break — Feb. 14-16 — and the Lakers could be out of the playoff picture by the time he’s back. The Lakers did so well in keeping the team around .500 until his return.How much more can a team endure? They weren’t a lock for the playoffs when everyone was healthy.“I wasn’t expecting this coming to practice (Thursday),” guard Nick Young said while shaking his head. “None of us were … It’s shocking. It’s like a roller coaster. We played a certain way without him. Then he came back and we played a certain way and got in a groove and played comfortable. We have to play for him and for each other.”There’s no way for the Lakers to spin this into something positive. They tried after practice, which is what they should do.Young had his usual smile going for the cameras, but he surely wanted to grit his teeth. “It’s rough,” Young said. “We rely on Kobe. We were getting comfortable with him. Things started to click. We were seeing what we wanted. Now, no point guards. No Kobe. No Jordan. No Blake. It’s something new every day.” The stunning injury, so soon after he returned from a long rehabilitation, confirms Bryant is getting much older, and his best days seem further and further behind him.“I was hoping this season he’d be healthier than he was last year,” Lakers center Pau Gasol said. “But it’s been one after another. It’s not going to be an excuse for us to not go out there and do our best and to continue to compete and try to get wins.”It’s difficult to know if one injury had anything to do with the other. Perhaps it was overcompensation. Maybe he came back too soon. D’Antoni had other ideas. “That’s just bad luck,” D’Antoni said of the injury.The Lakers tried to put on a good face, and after practice, the Lakers were next door to the ice skating rink for a Christmas party for children. Pau Gasol even donned a Santa hat and took pictures with children. It surely was a nice reprieve from a bummer day. And it must’ve been better than sitting around thinking about the future of this Laker season.Bryant was the only one who didn’t attend the party, but then again, he was at a doctor’s office where there was little Christmas cheer.Once again, he can do nothing to help the Lakers try to make the playoffs. The Lakers are fourth in the Pacific Division at 12-13 and 3 1/2 games out of playoff spotBryant injured his knee in a collision with Memphis’ Tony Allen on Tuesday, and the video that’s gone viral has everyone wondering what in the world happened that caused a fracture in his knee.It doesn’t seem anything significant happened before Bryant fell to the court and clutched his knee.We’re so used to watching Bryant play through seemingly anything with that Mamba look on his face, draining last-second shots and drawing fouls and being aggressive.The reality is that over the last year, he’s been on the bench or in the training room way more than he’s been on a basketball court. While his teammates were practicing Thursday, Bryant was getting an MRI. A reporter asked why Bryant wouldn’t just shut it down for the season. Anyone who knows Bryant’s competitive nature, knows that won’t happen.“He’s too much of a competitor to do that,” D’Antoni said. “If he decides to do that, there will be a discussion. I think he’ll be back in six weeks, and he’ll be hunting for some bear.”And the Lakers will be way far out, hunting for an elusive playoff [email protected] @jillpainter on Twittercenter_img All the Lakers wanted for Christmas was a healthy Kobe Bryant.Their holiday wish was nearly granted, with Bryant finally settling into a basketball rhythm, six games back after his return from a ruptured Achilles tendon.Then Santa delivered a shocker Thursday, six days before Christmas: Bryant has a fractured left knee and will be out at least six weeks.Tickets for the Christmas showdown with LeBron James and the Miami Heat at Staples Center are now akin to a lump of coal in your stocking.last_img read more

Oly Town Artesians’ Collin Labranche Named Eplwa Defensive Player of the…

first_imgFacebook4Tweet0Pin0Submitted by Oly Town ArtesiansOly Town Artesians defender Collin LaBranche was named the Evergreen Premier League Defensive Player of the Week on Wednesday. The Olympia High School alum was playing in his first game for the Artesians this season after graduating from Saint Martin’s last week and led the club to a 3-0 win over the Tri-Cities Alliance in Pasco.Despite a talented squad, the Artesians got off to a rough start to the season but got a nice boost with the return of LaBranche and a couple of other Saint Martin’s players. They played their most complete game on Sunday at Edgar Brown Stadium and picked up their first win of the season and are very much alive in the EPLWA’S Cascade Conference. LaBranche, who will return for one more season with the Saints this fall, won every challenge that came his way and solidified a backline that had struggled over the first two weeks.This is the sixth time that an Oly Town player has been honored with a Defensive POTW award in their three seasons in the EPLWA. Nate Boatright and Kyle Wiese won the award in 2017 and JJ Olson, Crisantos Chavez and Marcos Borja were all honored during the 2018 season.The Artesians will give LaBranche and their players a well deserved break for the Memorial Day weekend but will be back in action on Sunday, June 2nd when they host the second round of the Washington State Super Cup at Black Hills High School. They will face either BeSea FC of Bellevue or ISC Gunners of Issaquah in the second round of the statewide, single elimination tournament. First kick is set for 4:00 p.m.Oly returns to EPLWA action on Sunday, June 9th when Bellingham United visits Black Hills. It is Artesians 500 night and Oly Town will attempt to pack the park by offering soccer clubs, teams and other non-profits the opportunity to raise some funds by selling tickets. If your club or non-profit would like to raise some money, watch some soccer and have some fun, contact the Artesians at [email protected] or by calling Brandon Sparks at 360-561-7252.Stay up to date with the Artesians by visiting the Oly Town Artesians website, following them on Twitter, and liking them on Facebook.last_img read more

Photo library: South Africa at work 11

first_img{loadposition tc}Click on a thumbnail for a low-resolution image, or right-click on the link below it to download a high-resolution copy of the image.» Download South Africa at Work contact sheet (1.5MB) » Download full image library contact sheet (10.5MB) Welkom, Free State province: Repairs being made to underground equipment at the workshop at Harmony Gold Mine. Photo: Graeme Williams, » Download high-res image Welkom, Free State province: CAD draftsperson Elma Senekal at work at Harmony Gold Mine. Photo: Graeme Williams, » Download high-res image Welkom, Free Stateprovince: Underground plan details being added at Harmony Gold Mine.Photo: Graeme » Download high-res image Welkom, Free State province: Management and surveyors discuss developments at Harmony Gold Mine.Photo:Graeme » Download high-res image Welkom, Free State province: Management and surveyors discuss developments at Harmony Gold Mine.Photo: Graeme Williams » Download high-res image Working underground at a mine owned by Sasol, South Africa’s petrochemicals giant. Photo: Sasol » Download high-res image Workers at a plant owned by Sasol, South Africa’s petrochemicals giant. Photo: Sasol » Download high-res image Workers at a plant owned by Sasol, South Africa’s petrochemicals giant. Photo: Sasol » Download high-res image Workers at a plant owned by Sasol, South Africa’s petrochemicals giant. Photo: Sasol » Download high-res image SOUTH AFRICA AT WORK 11: {loadposition saatwork}Having trouble downloading high-resolution images? Queries about the image library? Email Janine Erasmus at [email protected]last_img read more

How to use Media Club South Africa’s free photo library

first_imgAll you need to know about locating and downloading high-resolution images from Media Club South Africa’s free photo library.One of Media Club South Africa’s offerings is a free photo library containing over 3 000 images of people and places across South Africa.The photos are available in low resolution (50KB to 200KB in size) and in high, print-ready resolution (1MB to over 10MB in size) – free of any charge.The photos are organised into 12 categories. PeopleCitiesInfrastructureBusiness and industrySouth Africa at workArts and cultureTourism and leisureNatureCountrysideDevelopmentBuildings and structuresSoccer fans and stadiumsTo download the high-resolution version, right-click on “Download high-res image” below the thumbnail and select “Save … as” (wording varies by browser) to save a copy of the photo onto your computer. If you republish the photos on the web or in print you are obliged to credit both the photographer and Media Club South Africa.On the web, this credit must include a link to Media Club South Africa.See also:Photo library terms and conditions of usePhoto library previewIf you have any further queries, or need help, email Mary Alexander at [email protected]last_img read more

Louis Oosthuizen captures Africa Open

first_imgOosthuizen birdied the first hole of a sudden-death playoff to beat England’s Chris Wood and Spain’s Manuel Quiros to the title, which is his third on the European Tour and signalled a welcome return to top form after he struggled with an injury towards the end of 2010. “The whole day was a struggle actually. It was one of those tournaments where the putter was very cold. But my caddie Zack told me to just be patient and the putts will drop,” said Oosthuizen. Charl Schwartzel put on a good show in defence of his title and posted a 70 to finish alongside Jaco van Zyl and Steven O’Hara on 15-under-par 277, only one shot behind the leading trio. Oosthuizen now leaves South Africa for a few tournaments on the European Tour before joining the PGA Tour, and admits he’s excited about this new chapter in his life. ‘Ecstatic’“It’s a great way to start the season. This is my first European Tour title in South Africa and I’m quite ecstatic about that,” said Oosthuizen, whose winner’s cheque of €158 500 (almost R1.4-million) helped lift him to the top of the Race to Dubai standings. “I’m looking forward to the whole year, playing half in America and Europe. I’m looking forward to contending on both money lists.” “It was a terrible tee shot, but it worked out well because I had a flat lie and could hit a full sand wedge, so I knew with a bit of spin I could get it close,” said Oosthuizen, who went on to hit his second shot to five metres from the hole. LEADERBOARD Quiros found his own putting form with three birdies in the final three holes to also make the playoff. Louis Oosthuizen (-16) 70, 67, 69, 70, 276 Chris Wood (-16) 72, 69, 67, 68, 276 Manuel Quiros (-16) 71, 68, 68, 69, 276 Steven O’Hara (-15) 72, 71, 68, 66, 277 Jaco van Zyl (-15) 67, 70, 70, 70, 277 Charl Schwartzel (-15) 69, 70, 68, 70, 277 Robert Dinwiddie (-14) 69, 74, 66, 69, 278Shaun Norris (-13) 70, 73, 70, 66, 279 Eirik Tage Johansen (-13) 71, 71, 70, 67, 279 Branden Grace (-13) 67, 69, 72, 71, 279 Miles Tunnicliff (-13) 67, 69, 72, 71, 279 Jbe Kruger (-13) 68, 72, 67, 72, 279 Markus Brier (-13) 70, 66, 70, 73, 279 Matthew Nixon (-12) 71, 74, 68, 67, 280 Oliver Bekker (-12) 69, 71, 69, 71, 280 Carlos Del Moral (-12) 70, 70, 69, 71, 280 Thomas Aiken (-12) 69, 72, 68, 71, 280 The Open champion closed with a 70, Wood a 68, and Quiros a 69 to see them all tied on 16-under-par. That putt finally arrived on the par-five 15th green, where Oosthuizen holed out for eagle from about 12 metres to share the lead with Wood on 15-under. But he was denied the sole lead when his birdie putt on 16 lipped out.center_img “I wasn’t expecting much having not practiced much with all the snow at home. But when you’re in a position to win, it’s disappointing not to do it. I didn’t do much wrong and can’t really fault myself, but it just didn’t happen for me.” Louis Oosthuizen added another Open to his list of victories when he won the Africa Open after a three-man playoff at the East London Golf Club on Sunday. DisappointmentFor rising English star Chris Wood, there was disappointment at not following through to claim a maiden victory on the European Tour. Oosthuizen, meanwhile, kept at it and tied for the lead on the 15th with an eagle. He needed a birdie on one of the three remaining holes to take victory, but managed only pars to set up the playoff. Luckily for him, he found the birdie he needed at the first extra hole. SAinfo reporter The South African had been tied for the third round lead with Markus Brier, but the Austrian made a storming start, with three consecutive birdies to take the sole lead. However, a lost ball on the sixth saw Brier slip back and he never recovered. Birdie for victoryWood hit his approach to about 10 metres, while Quiros went just over the back of the green. Both Quiros and Wood parred the hole, leaving Oosthuizen to make his putt for birdie and the win. 10 January 2011 Teeing off first in the playoff on the par-four 18th, Oosthuizen didn’t hit the best of tee shots and came close to out of bounds before it kicked right and rolled onto the fairway. Would you like to use this article in your publication or on your website? See: Using SAinfo materiallast_img read more

South Africa’s stem cell milestone

first_imgA microscopic view of brain cells generated from induced pluripotent stem cells in the laboratory of the University of Wisconsin-Madison. (Image: Su-Chun Zhang/Baoyang Hu, UW-Madison) MEDIA CONTACTS • Tendani Tsedu   CSIR Media Relations Manager  +27 12 841 3417 RELATED ARTICLES • Yes, it is rocket science • Digital drum boosts computer literacy • Hi-tech solution to fix roads • SA plant scientist reaps top award Wilma den HartighA group of researchers at South Africa’s Council for Scientific and Industrial Research (CSIR) have become the first in Africa to make a breakthrough in biomedical stem cell technology, making it possible to find cures to some of the continent’s most significant diseases.The CSIR’s gene expression and biophysics group, headed by Dr Musa Mhlanga, have generated the first induced pluripotent stem cells (iPSCs) in Africa.These cells are artificial, non-embryonic and iPSC technology makes it possible to transform adult cells, such as those found in the skin, into stem cells.As part of the research, Dr Janine Scholefield, one of the key researchers involved in generating iPSCs, recently demonstrated – using recorded video footage of rhythmically beating cells through a microscope in the laboratory – just how remarkable these cells are.In the video, the beating pattern is easily recognisable as heart muscle cells, but these cells did not come from a heart. They were transformed into heart cells from those taken from adult skin.This is the basis of iPSC technology: Early stem cells can be programmed to become any type of adult cell such as skin, heart, brain and blood cells.The CSIR simulated techniques devised by Japanese scientists in 2006 and 2007, that showed how an adult cell, such as a skin cell, could be induced it to become a stem cell.“This was a remarkable piece of scientific research,” says Scholefield.Part of the novelty of this technology lies in the fact that stem cells can be made from almost any individual with just about any disease, by simply taking a skin sample from that person.Benefits for AfricaThe capacity to grow such stem cells in South Africa is a major breakthrough for medical science as it is changing the way in which researchers are able to investigate, understand and find cures for diseases.“With iPSC technology established in South Africa, we can study diseases relevant to Africa,” says Scholefield.The development of iPSC technology also creates new possibilities for international investment in this particular research field.Says Scholefield: “South Africa and Africa have the most diverse and oldest genetic population, which means that we should study health, development and disease in our specific genetic backgrounds more vigorously.”The research team hopes that pharmaceutical companies would come on board to perform drug screening with African-derived samples, focused on diseases that affect people who live in Africa.According to Mhlanga, it is important to ensure that such medical advances are used in the developing world to find solutions to Africa’s high disease burden.Important for regenerative medicineThe medical possibilities of iPSCs are far reaching. Scientists can grow new tissue that can restore sight by replacing defective tissue in the eye; transplant new heart muscle cells into people with heart disease and give people with anaemia new healthy blood cells. It is also possible to treat disorders such as Parkinson’s disease.“Our genetics play a tremendous part in our susceptibility to disease, both in terms of inherited and acquired diseases,” Scholefield explains.Mutations in genes make some people more susceptible to Parkinson’s disease than others. Some people are also more vulnerable to infectious diseases such as Tuberculosis.“If we could study their cells, with a full complement of their genetic background in those cells in the laboratory, we’d potentially be able to uncover clues as to why they are able to hold off disease,” she says.Another way to utilise the technology is to create what is known as ‘disease in a dish’ models. This technique allows for testing of possible cures, or understanding a disease, without having to subject a patient to invasive surgery or untested trial medication.Complex technologySouth Africa is one of few countries that can use iPSC technology. The ability to grow stem cells is considered a complex skill that is only used by a handful of institutions in Japan, the United States, Europe and Australia.Scholefield explains that using the technology requires expertise in a number of different techniques that have to be performed perfectly.“To give you an idea of the difficulty, if you started with 100 000 skin cells, on average, only one of those will become a stem cell,” she says.“One needs to identify the shape change in skin cells, which requires weeks of patience and careful technique to identify the stem cells that arise.”In South Africa, only one other group headed by professors Susan Kidson and Jacquie Greenberg at the University of Cape Town is attempting to establish iPSC technology from human cells.Ethical issuesAnother benefit of using iPSCs is that they bypass the ethical controversy surrounding classical stem cells, which must be taken from embryos.As iPSCs are generated from adult skin, they bypass the ethical issues of embryonic stem cells (ESCs), while retaining most of ESCs abilities,” says Scholefield.“The only ethical consideration here is in the informed consent of the person donating the skin cells.”last_img read more